Halogenase-Targeted Genome Mining Leads to the Discovery of (±) Pestalachlorides A1a, A2a, and Their Atropisomers

Genome mining has become an important tool for discovering new natural products and identifying the cryptic biosynthesis gene clusters. Here, we utilized the flavin-dependent halogenase GedL as the probe in combination with characteristic halogen isotope patterns to mine new halogenated secondary me...

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Detalles Bibliográficos
Autores principales: Luo, Mengna, Wang, Mengyuan, Chang, Shanshan, He, Ning, Shan, Guangzhi, Xie, Yunying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598291/
https://www.ncbi.nlm.nih.gov/pubmed/36289962
http://dx.doi.org/10.3390/antibiotics11101304

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598291/
https://www.ncbi.nlm.nih.gov/pubmed/36289962
http://dx.doi.org/10.3390/antibiotics11101304

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