Introduction of a More Glutaredoxin-like Active Site to PDI Results in Competition between Protein Substrate and Glutathione Binding

Proteins in the thioredoxin superfamily share a similar fold, contain a -CXXC- active site, and catalyze oxidoreductase reactions by dithiol-disulfide exchange mechanisms. Protein disulfide isomerase (PDI) has two -CGHC- active sites. For in vitro studies, oxidation/reduction of PDI during the catal...

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Detalles Bibliográficos
Autores principales: Saaranen, Mirva J., Alanen, Heli I., Salo, Kirsi E. H., Nji, Emmanuel, Kärkkäinen, Pekka, Schmotz, Constanze, Ruddock, Lloyd W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598436/
https://www.ncbi.nlm.nih.gov/pubmed/36290643
http://dx.doi.org/10.3390/antiox11101920

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598436/
https://www.ncbi.nlm.nih.gov/pubmed/36290643
http://dx.doi.org/10.3390/antiox11101920

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