Activity of the Lactate Dehydrogenase Inhibitor Oxamic Acid against the Fermentative Bacterium Streptococcus mitis/oralis: Bactericidal Effects and Prevention of Daptomycin Resistance In Vitro and in an Ex Vivo Model

Streptococcus mitis/oralis is a fermentative bacterium that relies on lactate dehydrogenase to balance its redox poise and keep glycolysis active. Metabolomic analysis of an in vitro–derived daptomycin-resistant (DAP-R) S. mitis/oralis strain (351-D10) revealed differences in glucose catabolism rela...

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Detalles Bibliográficos
Autores principales: Kebriaei, Razieh, Bayer, Arnold S., Lapitan, Christian K., Rybak, Michael J., Somerville, Greg A., Mishra, Nagendra N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598551/
https://www.ncbi.nlm.nih.gov/pubmed/36290066
http://dx.doi.org/10.3390/antibiotics11101409

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598551/
https://www.ncbi.nlm.nih.gov/pubmed/36290066
http://dx.doi.org/10.3390/antibiotics11101409

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