Dipeptide Repeat Pathology in C9orf72-ALS Is Associated with Redox, Mitochondrial and NRF2 Pathway Imbalance

The hexanucleotide expansion of the C9orf72 gene is found in 40% of familial amyotrophic lateral sclerosis (ALS) patients. This genetic alteration has been connected with impaired management of reactive oxygen species. In this study, we conducted targeted transcriptional profiling in leukocytes from...

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Detalles Bibliográficos
Autores principales: Jiménez-Villegas, José, Kirby, Janine, Mata, Ana, Cadenas, Susana, Turner, Martin R., Malaspina, Andrea, Shaw, Pamela J., Cuadrado, Antonio, Rojo, Ana I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598689/
https://www.ncbi.nlm.nih.gov/pubmed/36290620
http://dx.doi.org/10.3390/antiox11101897

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598689/
https://www.ncbi.nlm.nih.gov/pubmed/36290620
http://dx.doi.org/10.3390/antiox11101897

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