A Multi-Specific DARPin Potently Neutralizes Shiga Toxin 2 via Simultaneous Modulation of Both Toxin Subunits

Shiga toxin-producing E. coli (STEC) is a common cause of bloody diarrhea. The pathology of STEC infection derives from two exotoxins—Shiga toxin 1 (Stx1) and Shiga toxin 2 (Stx2)—that are secreted by STEC in the gut, from where they are systemically absorbed, causing severe kidney damage leading to...

Descripción completa

Detalles Bibliográficos
Autores principales: Zeng, Yu, Jiang, Mengqiu, Robinson, Sally, Peng, Zeyu, Chonira, Vikas, Simeon, Rudo, Tzipori, Saul, Zhang, Junjie, Chen, Zhilei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598796/
https://www.ncbi.nlm.nih.gov/pubmed/36290479
http://dx.doi.org/10.3390/bioengineering9100511

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598796/
https://www.ncbi.nlm.nih.gov/pubmed/36290479
http://dx.doi.org/10.3390/bioengineering9100511

Ejemplares similares