Inhibition of Neddylation Suppresses Osteoclast Differentiation and Function In Vitro and Alleviates Osteoporosis In Vivo

Neddylation, or the covalent addition of NEDD8 to specific lysine residue of proteins, is a reversible posttranslational modification, which regulates numerous biological functions; however, its involvement and therapeutic significance in osteoporosis remains unknown. Our results revealed that durin...

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Detalles Bibliográficos
Autores principales: Wu, Meng-Huang, Hsu, Wei-Bin, Chen, Mei-Hsin, Shi, Chung-Sheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598818/
https://www.ncbi.nlm.nih.gov/pubmed/36289618
http://dx.doi.org/10.3390/biomedicines10102355

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598818/
https://www.ncbi.nlm.nih.gov/pubmed/36289618
http://dx.doi.org/10.3390/biomedicines10102355

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