MEKK-3 Acts Cooperatively with NSY-1 in SKN-1-Dependent Manner against Oxidative Stress and Aging in Caenorhabditis elegans

SIMPLE SUMMARY: Oxidative stress has been linked to myriad pathologies and aging. Here, we show that MEKK-3- and NSY-1-mediated nuclear translocation of SKN-1 is critical for protection against oxidative stress and for longevity in Caenorhabditis elegans. A genetic approach revealed that the knockdo...

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Detalles Bibliográficos
Autores principales: Hwang, Min, Shrestha, Chandani, Kang, Shinwon, Kim, Jiyoon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598901/
https://www.ncbi.nlm.nih.gov/pubmed/36290429
http://dx.doi.org/10.3390/biology11101526

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9598901/
https://www.ncbi.nlm.nih.gov/pubmed/36290429
http://dx.doi.org/10.3390/biology11101526

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