SMN Is Physiologically Downregulated at Wild-Type Motor Nerve Terminals but Aggregates Together with Neurofilaments in SMA Mouse Models

Survival motor neuron (SMN) is an essential and ubiquitously expressed protein that participates in several aspects of RNA metabolism. SMN deficiency causes a devastating motor neuron disease called spinal muscular atrophy (SMA). SMN forms the core of a protein complex localized at the cytoplasm and...

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Detalles Bibliográficos
Autores principales: Franco-Espin, Julio, Gatius, Alaó, Armengol, José Ángel, Arumugam, Saravanan, Moradi, Mehri, Sendtner, Michael, Calderó, Jordi, Tabares, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599093/
https://www.ncbi.nlm.nih.gov/pubmed/36291733
http://dx.doi.org/10.3390/biom12101524

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599093/
https://www.ncbi.nlm.nih.gov/pubmed/36291733
http://dx.doi.org/10.3390/biom12101524

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