Upregulation of Receptor Tyrosine Kinase Activity and Stemness as Resistance Mechanisms to Akt Inhibitors in Breast Cancer

SIMPLE SUMMARY: Acquired resistance of cancer cells to targeted therapy poses a major clinical problem. Hyperactivation of the PI3K/Akt pathway is common in human malignancies, and numerous Akt inhibitors are undergoing clinical evaluation. However, mechanisms of acquired resistance to Akt inhibitor...

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Detalles Bibliográficos
Autores principales: Tsang, Tiffany, He, Qingling, Cohen, Emily B., Stottrup, Casey, Lien, Evan C., Zhang, Huiqi, Lau, C. Geoffrey, Chin, Y. Rebecca
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599323/
https://www.ncbi.nlm.nih.gov/pubmed/36291790
http://dx.doi.org/10.3390/cancers14205006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599323/
https://www.ncbi.nlm.nih.gov/pubmed/36291790
http://dx.doi.org/10.3390/cancers14205006

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