Cargando…

c-Myc Sustains Pancreatic Cancer Cell Survival and mutp53 Stability through the Mevalonate Pathway

It has been shown that wild-type (wt)p53 inhibits oncogene c-Myc while mutant (mut)p53 may transactivate it, with an opposite behavior that frequently occurs in the crosstalk of wt or mutp53 with molecules/pathways promoting carcinogenesis. Even if it has been reported that mutp53 sustains c-Myc, wh...

Descripción completa

Detalles Bibliográficos
Autores principales:	Romeo, Maria Anele, Gilardini Montani, Maria Saveria, Arena, Andrea, Benedetti, Rossella, D’Orazi, Gabriella, Cirone, Mara
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599358/ https://www.ncbi.nlm.nih.gov/pubmed/36289751 http://dx.doi.org/10.3390/biomedicines10102489

Ejemplares similares

STAT3 and mutp53 Engage a Positive Feedback Loop Involving HSP90 and the Mevalonate Pathway
por: Romeo, Maria Anele, et al.
Publicado: (2020)

PBA Preferentially Impairs Cell Survival of Glioblastomas Carrying mutp53 by Reducing Its Expression Level, Stabilizing wtp53, Downregulating the Mevalonate Kinase and Dysregulating UPR
por: Romeo, Maria Anele, et al.
Publicado: (2020)

VPA and TSA Interrupt the Interplay between mutp53 and HSP70, Leading to CHK1 and RAD51 Down-Regulation and Sensitizing Pancreatic Cancer Cells to AZD2461 PARP Inhibitor
por: Romeo, Maria Anele, et al.
Publicado: (2022)

p53-R273H Sustains ROS, Pro-Inflammatory Cytokine Release and mTOR Activation While Reducing Autophagy, Mitophagy and UCP2 Expression, Effects Prevented by wtp53
por: Romeo, Maria Anele, et al.
Publicado: (2021)

Role of UPR Sensor Activation in Cell Death–Survival Decision of Colon Cancer Cells Stressed by DPE Treatment
por: Benedetti, Rossella, et al.
Publicado: (2021)

Targeting c-Myc Unbalances UPR towards Cell Death and Impairs DDR in Lymphoma and Multiple Myeloma Cells
por: Arena, Andrea, et al.
Publicado: (2022)

ATF6 prevents DNA damage and cell death in colon cancer cells undergoing ER stress
por: Benedetti, Rossella, et al.
Publicado: (2022)

NRF2 and STAT3: friends or foes in carcinogenesis?
por: Arena, Andrea, et al.
Publicado: (2023)

Lovastatin reduces PEL cell survival by phosphorylating ERK1/2 that blocks the autophagic flux and engages a cross‐talk with p53 to activate p21
por: Santarelli, Roberta, et al.
Publicado: (2021)

NFE2L2 and STAT3 Converge on Common Targets to Promote Survival of Primary Lymphoma Cells
por: Arena, Andrea, et al.
Publicado: (2023)

Mutant p53, Stabilized by Its Interplay with HSP90, Activates a Positive Feed-Back Loop Between NRF2 and p62 that Induces Chemo-Resistance to Apigenin in Pancreatic Cancer Cells
por: Gilardini Montani, Maria Saveria, et al.
Publicado: (2019)

Concomitant Inhibition of IRE1α/XBP1 Axis of UPR and PARP: A Promising Therapeutic Approach against c-Myc and Gammaherpesvirus-Driven B-Cell Lymphomas
por: Benedetti, Rossella, et al.
Publicado: (2022)

Acetylation increases expression, interaction with TRAPPC4 and surface localization of PD-L1
por: Romeo, Maria Anele, et al.
Publicado: (2023)

Interplay between Endoplasmic Reticulum (ER) Stress and Autophagy Induces Mutant p53H273 Degradation
por: Garufi, Alessia, et al.
Publicado: (2020)

Apigenin, by activating p53 and inhibiting STAT3, modulates the balance between pro-apoptotic and pro-survival pathways to induce PEL cell death
por: Granato, Marisa, et al.
Publicado: (2017)

New Insights into Curcumin- and Resveratrol-Mediated Anti-Cancer Effects
por: Arena, Andrea, et al.
Publicado: (2021)

Quercetin Interrupts the Positive Feedback Loop Between STAT3 and IL-6, Promotes Autophagy, and Reduces ROS, Preventing EBV-Driven B Cell Immortalization
por: Granato, Marisa, et al.
Publicado: (2019)

Reduced chemotherapeutic sensitivity in high glucose condition: implication of antioxidant response
por: Garufi, Alessia, et al.
Publicado: (2019)

KSHV infection skews macrophage polarisation towards M2-like/TAM and activates Ire1 α-XBP1 axis up-regulating pro-tumorigenic cytokine release and PD-L1 expression
por: Gilardini Montani, Maria Saveria, et al.
Publicado: (2020)

Autophagy manipulation as a strategy for efficient anticancer therapies: possible consequences
por: Cirone, Mara, et al.
Publicado: (2019)

Cytotoxic Drugs Activate KSHV Lytic Cycle in Latently Infected PEL Cells by Inducing a Moderate ROS Increase Controlled by HSF1, NRF2 and p62/SQSTM1
por: Granato, Marisa, et al.
Publicado: (2018)

Viral Infection and Autophagy Dysregulation: The Case of HHV-6, EBV and KSHV
por: Romeo, Maria Anele, et al.
Publicado: (2020)

IRE1 Alpha/XBP1 Axis Sustains Primary Effusion Lymphoma Cell Survival by Promoting Cytokine Release and STAT3 Activation
por: Gonnella, Roberta, et al.
Publicado: (2021)

p62/SQSTM1/Keap1/NRF2 Axis Reduces Cancer Cells Death-Sensitivity in Response to Zn(II)–Curcumin Complex
por: Garufi, Alessia, et al.
Publicado: (2021)

Zinc Supplementation Enhances the Pro-Death Function of UPR in Lymphoma Cells Exposed to Radiation
por: Gonnella, Roberta, et al.
Publicado: (2022)

A ruthenium(II)-curcumin compound modulates NRF2 expression balancing the cancer cell death/survival outcome according to p53 status
por: Garufi, Alessia, et al.
Publicado: (2020)

HHV-6A Infection of Papillary Thyroid Cancer Cells Induces Several Effects Related to Cancer Progression
por: Mardente, Stefania, et al.
Publicado: (2023)

HSPs/STAT3 Interplay Sustains DDR and Promotes Cytokine Release by Primary Effusion Lymphoma Cells
por: Gonnella, Roberta, et al.
Publicado: (2023)

Mutant p53 and Cellular Stress Pathways: A Criminal Alliance That Promotes Cancer Progression
por: D’Orazi, Gabriella, et al.
Publicado: (2019)

Bortezomib promotes KHSV and EBV lytic cycle by activating JNK and autophagy
por: Granato, Marisa, et al.
Publicado: (2017)

The Impact of NRF2 Inhibition on Drug-Induced Colon Cancer Cell Death and p53 Activity: A Pilot Study
por: Garufi, Alessia, et al.
Publicado: (2022)

Reactivation of mutant p53 by capsaicin, the major constituent of peppers
por: Garufi, Alessia, et al.
Publicado: (2016)

Capsaicin triggers immunogenic PEL cell death, stimulates DCs and reverts PEL-induced immune suppression
por: Granato, Marisa, et al.
Publicado: (2015)

Interconnected Adaptive Responses: A Way Out for Cancer Cells to Avoid Cellular Demise
por: D’Orazi, Gabriella, et al.
Publicado: (2022)

The Impact of COVID-19 Infection in Cancer 2020–2021
por: D’Orazi, Gabriella, et al.
Publicado: (2022)

NRF2 in Cancer: Cross-Talk with Oncogenic Pathways and Involvement in Gammaherpesvirus-Driven Carcinogenesis
por: Cirone, Mara, et al.
Publicado: (2022)

3,4-Dihydroxyphenylethanol (DPE or Hydroxytyrosol) Counteracts ERK1/2 and mTOR Activation, Pro-Inflammatory Cytokine Release, Autophagy and Mitophagy Reduction Mediated by Benzo[a]pyrene in Primary Human Colonic Epithelial Cells
por: Santarelli, Roberta, et al.
Publicado: (2022)

The Sweet Side of HIPK2
por: Garufi, Alessia, et al.
Publicado: (2023)

HIPK2 in Angiogenesis: A Promising Biomarker in Cancer Progression and in Angiogenic Diseases
por: Garufi, Alessia, et al.
Publicado: (2023)

Zinc supplementation is required for the cytotoxic and immunogenic effects of chemotherapy in chemoresistant p53-functionally deficient cells
por: Cirone, Mara, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_h0li8qb579ap5lu01hnult0485