Cargando…

Perturbations of mesenchymal stromal cells after allogeneic hematopoietic cell transplantation predispose for bone marrow graft-versus-host-disease

Functional impairment of the bone marrow (BM) niche has been suggested as a major reason for prolonged cytopenia and secondary graft failure after allogeneic hematopoietic cell transplantation (alloHCT). Because mesenchymal stromal cells (MSCs) serve as multipotent progenitors for several niche comp...

Descripción completa

Detalles Bibliográficos
Autores principales:	Krüger, Thomas, Wehner, Rebekka, Herbig, Maik, Kräter, Martin, Kramer, Michael, Middeke, Jan Moritz, Stölzel, Friedrich, List, Catrin, Egger-Heidrich, Katharina, Teipel, Raphael, Oelschlägel, Uta, Wermke, Martin, Jambor, Helena, Wobus, Manja, Schetelig, Johannes, Jöhrens, Korinna, Tonn, Torsten, Subburayalu, Julien, Schmitz, Marc, Bornhauser, Martin, von Bonin, Malte
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2022
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599394/ https://www.ncbi.nlm.nih.gov/pubmed/36311725 http://dx.doi.org/10.3389/fimmu.2022.1005554

Ejemplares similares

Long-Term Mixed Chimerism After Ex Vivo/In Vivo T Cell-Depleted Allogeneic Hematopoietic Cell Transplantation in Patients With Myeloid Neoplasms
por: Ruhnke, Leo, et al.
Publicado: (2021)

Spheroid Culture of Mesenchymal Stromal Cells Results in Morphorheological Properties Appropriate for Improved Microcirculation
por: Tietze, Stefanie, et al.
Publicado: (2019)

Klonale Hämatopoese – Bedeutung für die Zelltherapie
por: Teipel, Raphael, et al.
Publicado: (2022)

Clonal hematopoiesis and its emerging effects on cellular therapies
por: von Bonin, Malte, et al.
Publicado: (2021)

Association of the EGF-TM7 receptor CD97 expression with FLT3-ITD in acute myeloid leukemia
por: Wobus, Manja, et al.
Publicado: (2015)

Immunomodulatory Properties of Mesenchymal Stromal Cells: An Update
por: Müller, Luise, et al.
Publicado: (2021)

Allogeneic Stem Cell Transplantation with Sequential Melphalan-Based Conditioning in AML: Residual Morphological Blast Count Determines the Risk of Relapse
por: Sockel, Katja, et al.
Publicado: (2022)

Pilot Study on Mass Spectrometry–Based Analysis of the Proteome of CD34(+)CD123(+) Progenitor Cells for the Identification of Potential Targets for Immunotherapy in Acute Myeloid Leukemia
por: Schmidt, Johannes R., et al.
Publicado: (2018)

Zebrafish In-Vivo Screening for Compounds Amplifying Hematopoietic Stem and Progenitor Cells: - Preclinical Validation in Human CD34+ Stem and Progenitor Cells
por: Arulmozhivarman, Guruchandar, et al.
Publicado: (2017)

Editorial: Deciphering the bone marrow microenvironment in hematologic malignancies
por: Wobus, Manja, et al.
Publicado: (2023)

Machine learning assisted real-time deformability cytometry of CD34+ cells allows to identify patients with myelodysplastic syndromes
por: Herbig, Maik, et al.
Publicado: (2022)

Prevention and treatment of tumor lysis syndrome, and the efficacy and role of rasburicase
por: Alakel, Nael, et al.
Publicado: (2017)

Mesenchymal Stromal Cell-Derived Extracellular Vesicles Modulate Hematopoietic Stem and Progenitor Cell Viability and the Expression of Cell Cycle Regulators in an Age-dependent Manner
por: Fichtel, Pascal, et al.
Publicado: (2022)

Prevalence and variation of CHIP in patients with aggressive lymphomas undergoing CD19-directed CAR T-cell treatment
por: Teipel, Raphael, et al.
Publicado: (2022)

T-cell receptor-α repertoire of CD8+ T cells following allogeneic stem cell transplantation using next-generation sequencing
por: Link-Rachner, Cornelia S., et al.
Publicado: (2019)

Long-term in vivo imaging reveals tumor-specific dissemination and captures host tumor interaction in zebrafish xenografts
por: Asokan, Nandini, et al.
Publicado: (2020)

Myelodysplastic Syndromes and Metabolism
por: Balaian, Ekaterina, et al.
Publicado: (2021)

Gamma irradiation preserves immunosuppressive potential and inhibits clonogenic capacity of human bone marrow-derived mesenchymal stromal cells
por: de Andrade, Ana Valéria Gouveia, et al.
Publicado: (2014)

AIDeveloper: Deep Learning Image Classification in Life Science and Beyond
por: Kräter, Martin, et al.
Publicado: (2021)

Case Report: ANXA2 Associated Life-Threatening Coagulopathy With Hyperfibrinolysis in a Patient With Non-APL Acute Myeloid Leukemia
por: Ruhnke, Leo, et al.
Publicado: (2021)

Luspatercept restores SDF-1-mediated hematopoietic support by MDS-derived mesenchymal stromal cells
por: Wobus, Manja, et al.
Publicado: (2021)

Azacytidine impairs NK cell activity in AML and MDS patients undergoing MRD-based pre-emptive treatment after allogeneic stem cell transplantation
por: Schönefeldt, C, et al.
Publicado: (2013)

Distribution and levels of cell surface expression of CD33 and CD123 in acute myeloid leukemia
por: Ehninger, A, et al.
Publicado: (2014)

Symptomatic central nervous system involvement in adult patients with acute myeloid leukemia
por: Alakel, Nael, et al.
Publicado: (2017)

Bone marrow niche-mimetics modulate HSPC function via integrin signaling
por: Kräter, Martin, et al.
Publicado: (2017)

In Vivo Expansion of Co-Transplanted T Cells Impacts on Tumor Re-Initiating Activity of Human Acute Myeloid Leukemia in NSG Mice
por: von Bonin, Malte, et al.
Publicado: (2013)

Prognostic impact of the post-treatment T cell composition and spatial organization in soft tissue sarcoma patients treated with neoadjuvant hyperthermic radio(chemo)therapy
por: Rupp, Luise, et al.
Publicado: (2023)

Erythropoietin inhibits osteoblast function in myelodysplastic syndromes via the canonical Wnt pathway
por: Balaian, Ekaterina, et al.
Publicado: (2018)

Peptidyl prolyl cis/trans isomerase activity on the cell surface correlates with extracellular matrix development
por: Lin, Weilin, et al.
Publicado: (2019)

OXPHOS Supercomplexes as a Hallmark of the Mitochondrial Phenotype of Adipogenic Differentiated Human MSCs
por: Hofmann, Andreas D., et al.
Publicado: (2012)

Human Bone Marrow Stromal Cells: A Reliable, Challenging Tool for In Vitro Osteogenesis and Bone Tissue Engineering Approaches
por: Hempel, Ute, et al.
Publicado: (2016)

Mesenchymal stromal cell-associated migrasomes: a new source of chemoattractant for cells of hematopoietic origin
por: Deniz, Ilker A., et al.
Publicado: (2023)

Fascia training in patients undergoing allogeneic hematopoietic cell transplantation—a pilot study
por: Weigmann-Faßbender, Sandra, et al.
Publicado: (2022)

The Challenge to the Pathologist of PD-L1 Expression in Tumor Cells of Non-Small-Cell Lung Cancer—An Overview
por: Jöhrens, Korinna, et al.
Publicado: (2021)

The prevalence of extramedullary acute myeloid leukemia detected by (18)FDG-PET/CT: final results from the prospective PETAML trial
por: Stölzel, Friedrich, et al.
Publicado: (2020)

Deep learning identifies Acute Promyelocytic Leukemia in bone marrow smears
por: Eckardt, Jan-Niklas, et al.
Publicado: (2022)

P528: CAN MULTIPARAMETRIC FLOW CYTOMETRY OF PERIPHERAL BLOOD CHALLENGE BONE MARROW ANALYSES FOR DETECTION OF MEASURABLE RESIDUAL DISEASE IN PATIENTS WITH ACUTE MYELOID LEUKEMIA?
por: Schadt, Jonas, et al.
Publicado: (2023)

Spatial heterogeneity and differential treatment response of acute myeloid leukemia and relapsed/refractory extramedullary disease after allogeneic hematopoietic cell transplantation
por: Kunadt, Desiree, et al.
Publicado: (2022)

Depressive disorders are associated with increased peripheral blood cell deformability: a cross-sectional case-control study (Mood-Morph)
por: Walther, Andreas, et al.
Publicado: (2022)

Reinforcement Learning for Precision Oncology
por: Eckardt, Jan-Niklas, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t0akl6sk5622ul170581p3sr42