Dual inhibition of BET and HAT/p300 suppresses colorectal cancer via DR5- and p53/PUMA-mediated cell death

BACKGROUND: Colorectal cancer (CRC) frequently has a dysregulated epigenome causing aberrant up-regulation of oncogenes such as c-MYC. Bromodomain and extra-terminal domain (BET) proteins and histone acetyltransferases (HAT) are epigenetic regulatory proteins that create and maintain epigenetic stat...

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Detalles Bibliográficos
Autores principales: Kuang, Chaoyuan, Tong, Jingshan, Ermine, Kaylee, Cai, Manbo, Dai, Fujun, Hao, Suisui, Giles, Francis, Huang, Yi, Yu, Jian, Zhang, Lin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Oncology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599411/
https://www.ncbi.nlm.nih.gov/pubmed/36313707
http://dx.doi.org/10.3389/fonc.2022.1018775

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599411/
https://www.ncbi.nlm.nih.gov/pubmed/36313707
http://dx.doi.org/10.3389/fonc.2022.1018775

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