The β-Grasp Domain of Proteasomal ATPase Mpa Makes Critical Contacts with the Mycobacterium tuberculosis 20S Core Particle to Facilitate Degradation

Mycobacterium tuberculosis possesses a Pup-proteasome system analogous to the eukaryotic ubiquitin-proteasome pathway. We have previously shown that the hexameric mycobacterial proteasome ATPase (Mpa) recruits pupylated protein substrates via interactions between amino-terminal coiled-coils in Mpa m...

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Detalles Bibliográficos
Autores principales: Xiao, Xiansha, Feng, Xiang, Yoo, Jin Hee, Kovach, Amanda, Darwin, K. Heran, Li, Huilin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599533/
https://www.ncbi.nlm.nih.gov/pubmed/35993699
http://dx.doi.org/10.1128/msphere.00274-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599533/
https://www.ncbi.nlm.nih.gov/pubmed/35993699
http://dx.doi.org/10.1128/msphere.00274-22

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