Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b

Pancreatic ductal adenocarcinoma (PDAC) cells are known for their high invasive/metastatic potential, which is regulated in part by the transforming growth factor β1 (TGFβ1). The involvement of at least two type I receptors, ALK5 and ALK2, that transmit downstream signals of the TGFβ via different S...

Descripción completa

Detalles Bibliográficos
Autores principales: Ungefroren, Hendrik, Braun, Rüdiger, Lapshyna, Olha, Konukiewitz, Björn, Wellner, Ulrich F., Lehnert, Hendrik, Marquardt, Jens-Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599656/
https://www.ncbi.nlm.nih.gov/pubmed/36289908
http://dx.doi.org/10.3390/biomedicines10102640

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599656/
https://www.ncbi.nlm.nih.gov/pubmed/36289908
http://dx.doi.org/10.3390/biomedicines10102640

Ejemplares similares