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Suppressive Role of ACVR1/ALK2 in Basal and TGFβ1-Induced Cell Migration in Pancreatic Ductal Adenocarcinoma Cells and Identification of a Self-Perpetuating Autoregulatory Loop Involving the Small GTPase RAC1b

Pancreatic ductal adenocarcinoma (PDAC) cells are known for their high invasive/metastatic potential, which is regulated in part by the transforming growth factor β1 (TGFβ1). The involvement of at least two type I receptors, ALK5 and ALK2, that transmit downstream signals of the TGFβ via different S...

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Detalles Bibliográficos
Autores principales:	Ungefroren, Hendrik, Braun, Rüdiger, Lapshyna, Olha, Konukiewitz, Björn, Wellner, Ulrich F., Lehnert, Hendrik, Marquardt, Jens-Uwe
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599656/ https://www.ncbi.nlm.nih.gov/pubmed/36289908 http://dx.doi.org/10.3390/biomedicines10102640

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