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Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort

SIMPLE SUMMARY: The study explored pancreatic cancer (PaCa) risk factors in the UK Biobank cohort. The risk factors included non-modifiable risk factors: age, gender, and modifiable risk factors: cigarette smoking, overweight and obesity, increased waist circumstance, abdominal obesity, Diabetic Mel...

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Autores principales: Ke, Te-Min, Lophatananon, Artitaya, Muir, Kenneth R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599736/
https://www.ncbi.nlm.nih.gov/pubmed/36291775
http://dx.doi.org/10.3390/cancers14204991
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author Ke, Te-Min
Lophatananon, Artitaya
Muir, Kenneth R.
author_facet Ke, Te-Min
Lophatananon, Artitaya
Muir, Kenneth R.
author_sort Ke, Te-Min
collection PubMed
description SIMPLE SUMMARY: The study explored pancreatic cancer (PaCa) risk factors in the UK Biobank cohort. The risk factors included non-modifiable risk factors: age, gender, and modifiable risk factors: cigarette smoking, overweight and obesity, increased waist circumstance, abdominal obesity, Diabetic Mellitus (DM), and pancreatitis history. The study findings suggested that stopping cigarette smoking, avoiding overweight or obesity, abdominal obesity, Diabetic Mellitus, and pancreatitis history could contribute to a significant reduction in future PaCa cases if these exposures are avoided. ABSTRACT: Evidence on pancreatic cancer (PaCa) risk factors from large population-based cohort studies is limited. This study investigated the PaCa risk factors and the population attributable fraction (PAF) of modifiable risk factors in the UK Biobank cohort. The UK Biobank is a prospective cohort consisting of 502,413 participants with a mean follow-up time of 8.2 years. A binomial generalized linear regression model was used to calculate relative risks for PaCa risk factors. PAF was calculated to estimate the proportional reduction in PaCa if modifiable risk factors were to be eliminated. A total of 728 (0.14%) PaCa incident cases and 412,922 (82.19%) non-PaCa controls were analyzed. The non-modifiable risk factors included age and gender. The modifiable risk factors were cigarette smoking, overweight and obesity, increased waist circumstance, abdominal obesity, Diabetic Mellitus (DM), and pancreatitis history. The PAF suggested that eliminating smoking and obesity can contribute around a 16% reduction in PaCa cases while avoiding abdominal obesity can eliminate PaCa cases by 22%. Preventing pancreatitis and DM could potentially reduce PaCa cases by 1% and 6%, respectively. This study has identified modifiable and non-modifiable PaCa risk factors in the UK population. The PAF of modifiable risk factors can be applied to inform PaCa prevention programs.
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spelling pubmed-95997362022-10-27 Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort Ke, Te-Min Lophatananon, Artitaya Muir, Kenneth R. Cancers (Basel) Article SIMPLE SUMMARY: The study explored pancreatic cancer (PaCa) risk factors in the UK Biobank cohort. The risk factors included non-modifiable risk factors: age, gender, and modifiable risk factors: cigarette smoking, overweight and obesity, increased waist circumstance, abdominal obesity, Diabetic Mellitus (DM), and pancreatitis history. The study findings suggested that stopping cigarette smoking, avoiding overweight or obesity, abdominal obesity, Diabetic Mellitus, and pancreatitis history could contribute to a significant reduction in future PaCa cases if these exposures are avoided. ABSTRACT: Evidence on pancreatic cancer (PaCa) risk factors from large population-based cohort studies is limited. This study investigated the PaCa risk factors and the population attributable fraction (PAF) of modifiable risk factors in the UK Biobank cohort. The UK Biobank is a prospective cohort consisting of 502,413 participants with a mean follow-up time of 8.2 years. A binomial generalized linear regression model was used to calculate relative risks for PaCa risk factors. PAF was calculated to estimate the proportional reduction in PaCa if modifiable risk factors were to be eliminated. A total of 728 (0.14%) PaCa incident cases and 412,922 (82.19%) non-PaCa controls were analyzed. The non-modifiable risk factors included age and gender. The modifiable risk factors were cigarette smoking, overweight and obesity, increased waist circumstance, abdominal obesity, Diabetic Mellitus (DM), and pancreatitis history. The PAF suggested that eliminating smoking and obesity can contribute around a 16% reduction in PaCa cases while avoiding abdominal obesity can eliminate PaCa cases by 22%. Preventing pancreatitis and DM could potentially reduce PaCa cases by 1% and 6%, respectively. This study has identified modifiable and non-modifiable PaCa risk factors in the UK population. The PAF of modifiable risk factors can be applied to inform PaCa prevention programs. MDPI 2022-10-12 /pmc/articles/PMC9599736/ /pubmed/36291775 http://dx.doi.org/10.3390/cancers14204991 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Ke, Te-Min
Lophatananon, Artitaya
Muir, Kenneth R.
Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort
title Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort
title_full Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort
title_fullStr Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort
title_full_unstemmed Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort
title_short Risk Factors Associated with Pancreatic Cancer in the UK Biobank Cohort
title_sort risk factors associated with pancreatic cancer in the uk biobank cohort
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599736/
https://www.ncbi.nlm.nih.gov/pubmed/36291775
http://dx.doi.org/10.3390/cancers14204991
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