Shortened Hinge Design of Fab x sdAb-Fc Bispecific Antibodies Enhances Redirected T-Cell Killing of Tumor Cells

T cell engager (TCE) antibodies have emerged as promising cancer therapeutics that link cytotoxic T-cells to tumor cells by simultaneously binding to CD3E on T-cells and to a tumor-associated antigen (TAA) expressed by tumor cells. We previously reported a novel bispecific format, the IgG-like Fab x...

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Detalles Bibliográficos
Autores principales: Huang, Shuyu, Segués, Aina, Waterfall, Martin, Wright, David, Vayssiere, Charlotte, van Duijnhoven, Sander M. J., van Elsas, Andrea, Sijts, Alice J. A. M., Zaiss, Dietmar M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599842/
https://www.ncbi.nlm.nih.gov/pubmed/36291540
http://dx.doi.org/10.3390/biom12101331

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599842/
https://www.ncbi.nlm.nih.gov/pubmed/36291540
http://dx.doi.org/10.3390/biom12101331

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