Reshaping the Binding Pocket of the Neurotransmitter:Solute Symporter (NSS) Family Transporter SLC6A14 (ATB(0,+)) Selectively Reduces Access for Cationic Amino Acids and Derivatives

SLC6A14 (ATB(0,+)) is unique among SLC proteins in its ability to transport 18 of the 20 proteinogenic (dipolar and cationic) amino acids and naturally occurring and synthetic analogues (including anti-viral prodrugs and nitric oxide synthase (NOS) inhibitors). SLC6A14 mediates amino acid uptake in...

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Detalles Bibliográficos
Autores principales: Anderson, Catriona M. H., Edwards, Noel, Watson, Andrew K., Althaus, Mike, Thwaites, David T.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599917/
https://www.ncbi.nlm.nih.gov/pubmed/36291613
http://dx.doi.org/10.3390/biom12101404

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9599917/
https://www.ncbi.nlm.nih.gov/pubmed/36291613
http://dx.doi.org/10.3390/biom12101404

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