N-Succinyltransferase Encoded by a Cryptic Siderophore Biosynthesis Gene Cluster in Streptomyces Modifies Structurally Distinct Antibiotics

The antibiotic desertomycin A and its previously undescribed inactive N-succinylated analogue, desertomycin X, were isolated from Streptomyces sp. strain YIM 121038. Genome sequencing and analysis readily identified the desertomycin biosynthetic gene cluster (BGC), which lacked genes encoding acyltr...

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Detalles Bibliográficos
Autores principales: Schneider, Olha, Zehl, Martin, Ueoka, Reiko, Rückert, Christian, Buche, Tobias, Jiang, Yi, Li, Qin-Yuan, Piel, Jörn, Zotchev, Sergey B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600172/
https://www.ncbi.nlm.nih.gov/pubmed/36040031
http://dx.doi.org/10.1128/mbio.01789-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600172/
https://www.ncbi.nlm.nih.gov/pubmed/36040031
http://dx.doi.org/10.1128/mbio.01789-22

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