Cargando…

Vaccination with Live or Heat-Killed Aspergillus fumigatus ΔsglA Conidia Fully Protects Immunocompromised Mice from Invasive Aspergillosis

Aspergillus fumigatus causes invasive aspergillosis (IA) in immunocompromised patients, resulting in high mortality rates. Currently, no vaccine formulations to promote immune protection in at-risk individuals have been developed. In this work, we deleted the sterylglucosidase-encoding gene, sglA, i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fernandes, Caroline Mota, Normile, Tyler G., Fabri, Joao Henrique Tadini Marilhano, Brauer, Veronica Soares, de S. Araújo, Glauber R., Frases, Susana, Nimrichter, Leonardo, Malavazi, Iran, Del Poeta, Maurizio
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600187/ https://www.ncbi.nlm.nih.gov/pubmed/36066100 http://dx.doi.org/10.1128/mbio.02328-22

Ejemplares similares

Three Models of Vaccination Strategies Against Cryptococcosis in Immunocompromised Hosts Using Heat-Killed Cryptococcus neoformans Δsgl1
por: Normile, Tyler G., et al.
Publicado: (2022)

The Heat Shock Transcription Factor HsfA Plays a Role in Membrane Lipids Biosynthesis Connecting Thermotolerance and Unsaturated Fatty Acid Metabolism in Aspergillus fumigatus
por: Fabri, João Henrique Tadini Marilhano, et al.
Publicado: (2023)

The Heat Shock Transcription Factor HsfA Is Essential for Thermotolerance and Regulates Cell Wall Integrity in Aspergillus fumigatus
por: Fabri, João Henrique Tadini Marilhano, et al.
Publicado: (2021)

The AGC Kinase YpkA Regulates Sphingolipids Biosynthesis and Physically Interacts With SakA MAP Kinase in Aspergillus fumigatus
por: Fabri, João Henrique Tadini Marilhano, et al.
Publicado: (2019)

Cryptococcus neoformans Δsgl1 Vaccination Requires Either CD4(+) or CD8(+) T Cells for Complete Host Protection
por: Normile, Tyler G., et al.
Publicado: (2021)

Vaccine protection by Cryptococcus neoformans Δsgl1 is mediated by γδ T cells via TLR2 signaling
por: Normile, Tyler G., et al.
Publicado: (2022)

Aspergillus fumigatus MADS-Box Transcription Factor rlmA Is Required for Regulation of the Cell Wall Integrity and Virulence
por: Rocha, Marina Campos, et al.
Publicado: (2016)

Azole Resistance of Aspergillus fumigatus in Immunocompromised Patients with Invasive Aspergillosis
por: van der Linden, Jan W.M., et al.
Publicado: (2016)

Azole Resistance of Aspergillus fumigatus in Immunocompromised Patients with Invasive Aspergillosis
por: Alanio, Alexandre, et al.
Publicado: (2016)

Protein Kinase A and High-Osmolarity Glycerol Response Pathways Cooperatively Control Cell Wall Carbohydrate Mobilization in Aspergillus fumigatus
por: de Assis, Leandro José, et al.
Publicado: (2018)

Aspergillus fumigatus Strain-Specific Conidia Lung Persistence Causes an Allergic Broncho-Pulmonary Aspergillosis-Like Disease Phenotype
por: Jones, Jane T., et al.
Publicado: (2021)

Transcriptomic analysis of the exit from dormancy of Aspergillus fumigatus conidia
por: Lamarre, Claude, et al.
Publicado: (2008)

Isolation and immunofluorescence staining of Aspergillus fumigatus conidia-containing phagolysosomes
por: Goldmann, Marie, et al.
Publicado: (2021)

Phagocytosis of Aspergillus fumigatus conidia by primary nasal epithelial cells in vitro
por: Botterel, Françoise, et al.
Publicado: (2008)

Melanin is an essential component for the integrity of the cell wall of Aspergillus fumigatus conidia
por: Pihet, Marc, et al.
Publicado: (2009)

Host Soluble Mediators: Defying the Immunological Inertness of Aspergillus fumigatus Conidia
por: Wong, Sarah Sze Wah, et al.
Publicado: (2017)

Migrating Lung Monocytes Internalize and Inhibit Growth of Aspergillus fumigatus Conidia
por: Schiefermeier-Mach, Natalia, et al.
Publicado: (2020)

Innate and Adaptive Immune Responses Induced by Aspergillus fumigatus Conidia and Hyphae
por: Luo, Yingzhi, et al.
Publicado: (2022)

Targeting of phagolysosomes containing conidia of the fungus Aspergillus fumigatus with polymeric particles
por: González, Katherine, et al.
Publicado: (2022)

Analyses of the three 1-Cys Peroxiredoxins from Aspergillus fumigatus reveal that cytosolic Prx1 is central to H(2)O(2) metabolism and virulence
por: Rocha, Marina Campos, et al.
Publicado: (2018)

Dual Organism Transcriptomics of Airway Epithelial Cells Interacting with Conidia of Aspergillus fumigatus
por: Oosthuizen, Jean L., et al.
Publicado: (2011)

Elimination of Aspergillus fumigatus conidia from the airways of mice with allergic airway inflammation
por: Shevchenko, Marina A, et al.
Publicado: (2013)

Interactions of Aspergillus fumigatus Conidia with Airway Epithelial Cells: A Critical Review
por: Croft, Carys A., et al.
Publicado: (2016)

Effects of Aspergillus fumigatus Conidia on Apoptosis and Proliferation in an In Vitro Model of the Lung Microenvironment
por: Kushima, Hisako, et al.
Publicado: (2021)

Role of Sterylglucosidase 1 (Sgl1) on the pathogenicity of Cryptococcus neoformans: potential applications for vaccine development
por: Rella, Antonella, et al.
Publicado: (2015)

Aspergillosis myocarditis in the immunocompromised host
por: Bullis, Sean S., et al.
Publicado: (2019)

Genes Differentially Expressed in Conidia and Hyphae of Aspergillus fumigatus upon Exposure to Human Neutrophils
por: Sugui, Janyce A., et al.
Publicado: (2008)

Effects of antifungal agents on the production of cytokines from macrophages stimulated by Aspergillus fumigatus conidia
por: Choi, Jung-Hyun, et al.
Publicado: (2007)

Functional genomics of human bronchial epithelial cells directly interacting with conidia of Aspergillus fumigatus
por: Gomez, Pol, et al.
Publicado: (2010)

A Murine Inhalation Model to Characterize Pulmonary Exposure to Dry Aspergillus fumigatus Conidia
por: Buskirk, Amanda D., et al.
Publicado: (2014)

Automated quantification of the phagocytosis of Aspergillus fumigatus conidia by a novel image analysis algorithm
por: Kraibooj, Kaswara, et al.
Publicado: (2015)

Aspergillus fumigatus adhesion factors in dormant conidia revealed through comparative phenotypic and transcriptomic analyses
por: Takahashi‐Nakaguchi, Azusa, et al.
Publicado: (2017)

Endocytic Markers Associated with the Internalization and Processing of Aspergillus fumigatus Conidia by BEAS-2B Cells
por: Clark, Helen R., et al.
Publicado: (2019)

Effect of amphotericin B and voriconazole on the outgrowth of conidia of Aspergillus fumigatus followed by time-lapse microscopy
por: Talas, Laszlo, et al.
Publicado: (2019)

Cryptococcus neoformans Glucuronoxylomannan and Sterylglucoside Are Required for Host Protection in an Animal Vaccination Model
por: Colombo, Ana Caroline, et al.
Publicado: (2019)

Bacterial Interactions with Aspergillus fumigatus in the Immunocompromised Lung
por: Margalit, Anatte, et al.
Publicado: (2021)

Aspergillus fumigatus and aspergillosis: From basics to clinics
por: Arastehfar, A., et al.
Publicado: (2021)

Verruculogen associated with Aspergillus fumigatus hyphae and conidia modifies the electrophysiological properties of human nasal epithelial cells
por: Khoufache, Khaled, et al.
Publicado: (2007)

P118 Pentraxin-3 interacts with Aspergillus fumigatus conidia to regulate pro-inflammatory cytokine production
por: Dellière, Sarah, et al.
Publicado: (2022)

Transcription profile of Trichophyton rubrum conidia grown on keratin reveals the induction of an adhesin-like protein gene with a tandem repeat pattern
por: Bitencourt, Tamires Aparecida, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_avqcn8t4vfgkh6lhn88ddeevr7