Monitoring NLRP3 Inflammasome Activation and Exhaustion in Clinical Samples: A Refined Flow Cytometry Protocol for ASC Speck Formation Measurement Directly in Whole Blood after Ex Vivo Stimulation

Alteration of NLRP3 inflammasome pathway including hyper-activation or exhaustion has been implicated in the pathophysiology of many diseases. Following cell stimulation, aggregation of the ASC protein into a multiprotein complex, the ASC speck, has been proposed as a specific read-out for monitorin...

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Detalles Bibliográficos
Autores principales: Coudereau, Rémy, Gossez, Morgane, Py, Bénédicte F, Henry, Thomas, Lukaszewicz, Anne-Claire, Monneret, Guillaume, Venet, Fabienne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600366/
https://www.ncbi.nlm.nih.gov/pubmed/36291172
http://dx.doi.org/10.3390/cells11203306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600366/
https://www.ncbi.nlm.nih.gov/pubmed/36291172
http://dx.doi.org/10.3390/cells11203306

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