Efficient Synthesis with Green Chemistry Approach of Novel Pharmacophores of Imidazole-Based Hybrids for Tumor Treatment: Mechanistic Insights from In Situ to In Silico

SIMPLE SUMMARY: Here, we report the eco-friendly synthesis and antitumor potential of the imidazole hybrids of pyrimidine. The results showed that all the compounds possess excellent inhibition of tumors, promoting enzymes hCA-IX and hCA-II. Furthermore, the selectivity index showed that compounds 7...

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Detalles Bibliográficos
Autores principales: Khan, Majid, Shah, Syed Raza, Khan, Faizullah, Halim, Sobia Ahsan, Rahman, Shaikh Mizanoor, Khalid, Mohammad, Khan, Ajmal, Al-Harrasi, Ahmed
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600394/
https://www.ncbi.nlm.nih.gov/pubmed/36291864
http://dx.doi.org/10.3390/cancers14205079

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600394/
https://www.ncbi.nlm.nih.gov/pubmed/36291864
http://dx.doi.org/10.3390/cancers14205079

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