Genomic Amplification of UBQLN4 Is a Prognostic and Treatment Resistance Factor

Ubiquilin-4 (UBQLN4) is a proteasomal shuttle factor that directly binds to ubiquitylated proteins and delivers its cargo to the 26S proteasome for degradation. We previously showed that upregulated UBQLN4 determines the DNA damage response (DDR) through the degradation of MRE11A. However, the regul...

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Detalles Bibliográficos
Autores principales: Kobayashi, Yuta, Bustos, Matias A., Shoji, Yoshiaki, Jachimowicz, Ron D., Shiloh, Yosef, Hoon, Dave S. B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600423/
https://www.ncbi.nlm.nih.gov/pubmed/36291176
http://dx.doi.org/10.3390/cells11203311

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600423/
https://www.ncbi.nlm.nih.gov/pubmed/36291176
http://dx.doi.org/10.3390/cells11203311

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