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Preexisting Heterogeneity of Inducible Nitric Oxide Synthase Expression Drives Differential Growth of Mycobacterium tuberculosis in Macrophages

Mycobacterium tuberculosis infection is initiated by the inhalation and implantation of bacteria in the lung alveoli, where they are phagocytosed by macrophages. Even a single bacterium may be sufficient to initiate infection. Thereafter, the clinical outcome is highly variable between individuals,...

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Detalles Bibliográficos
Autores principales: Rutschmann, Ophélie, Toniolo, Chiara, McKinney, John D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600446/
https://www.ncbi.nlm.nih.gov/pubmed/36121153
http://dx.doi.org/10.1128/mbio.02251-22