Exosomal Plasma Gelsolin Is an Immunosuppressive Mediator in the Ovarian Tumor Microenvironment and a Determinant of Chemoresistance

Ovarian Cancer (OVCA) is the most fatal gynecologic cancer and has a 5-year survival rate less than 45%. This is mainly due to late diagnosis and drug resistance. Overexpression of plasma gelsolin (pGSN) is key contributing factor to OVCA chemoresistance and immunosuppression. Gelsolin (GSN) is a mu...

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Detalles Bibliográficos
Autores principales: Onuma, Toshimichi, Asare-Werehene, Meshach, Yoshida, Yoshio, Tsang, Benjamin K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600545/
https://www.ncbi.nlm.nih.gov/pubmed/36291171
http://dx.doi.org/10.3390/cells11203305

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600545/
https://www.ncbi.nlm.nih.gov/pubmed/36291171
http://dx.doi.org/10.3390/cells11203305

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