Structural and Mechanistic Bases of Viral Resistance to HIV-1 Capsid Inhibitor Lenacapavir

Lenacapavir (LEN) is a long-acting, highly potent HIV-1 capsid (CA) inhibitor. The evolution of viral variants under the genetic pressure of LEN identified Q67H, N74D, and Q67H/N74D CA substitutions as the main resistance associated mutations (RAMs). Here, we determined high-resolution structures of...

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Detalles Bibliográficos
Autores principales: Bester, Stephanie M., Adu-Ampratwum, Daniel, Annamalai, Arun S., Wei, Guochao, Briganti, Lorenzo, Murphy, Bridget C., Haney, Reed, Fuchs, James R., Kvaratskhelia, Mamuka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600929/
https://www.ncbi.nlm.nih.gov/pubmed/36190128
http://dx.doi.org/10.1128/mbio.01804-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9600929/
https://www.ncbi.nlm.nih.gov/pubmed/36190128
http://dx.doi.org/10.1128/mbio.01804-22

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