An Alzheimer’s Disease Patient-Derived Olfactory Stem Cell Model Identifies Gene Expression Changes Associated with Cognition

An early symptom of Alzheimer’s disease (AD) is an impaired sense of smell, for which the molecular basis remains elusive. Here, we generated human olfactory neurosphere-derived (ONS) cells from people with AD and mild cognitive impairment (MCI), and performed global RNA sequencing to determine gene...

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Detalles Bibliográficos
Autores principales: Rantanen, Laura M., Bitar, Maina, Lampinen, Riikka, Stewart, Romal, Quek, Hazel, Oikari, Lotta E., Cunί-Lόpez, Carla, Sutharsan, Ratneswary, Thillaiyampalam, Gayathri, Iqbal, Jamila, Russell, Daniel, Penttilä, Elina, Löppönen, Heikki, Lehtola, Juha-Matti, Saari, Toni, Hannonen, Sanna, Koivisto, Anne M., Haupt, Larisa M., Mackay-Sim, Alan, Cristino, Alexandre S., Kanninen, Katja M., White, Anthony R.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601087/
https://www.ncbi.nlm.nih.gov/pubmed/36291125
http://dx.doi.org/10.3390/cells11203258

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601087/
https://www.ncbi.nlm.nih.gov/pubmed/36291125
http://dx.doi.org/10.3390/cells11203258

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