Long-Term IGF1 Stimulation Leads to Cellular Senescence via Functional Interaction with the Thioredoxin-Interacting Protein, TXNIP

The growth hormone (GH)–insulin-like growth factor-1 (IGF1) signaling pathway plays a major role in orchestrating cellular interactions, metabolism, growth and aging. Studies from worms to mice showed that downregulated activity of the GH/IGF1 pathway could be beneficial for the extension of lifespa...

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Detalles Bibliográficos
Autores principales: Nagaraj, Karthik, Sarfstein, Rive, Laron, Zvi, Werner, Haim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601129/
https://www.ncbi.nlm.nih.gov/pubmed/36291127
http://dx.doi.org/10.3390/cells11203260

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601129/
https://www.ncbi.nlm.nih.gov/pubmed/36291127
http://dx.doi.org/10.3390/cells11203260

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