Polyubiquitination and SUMOylation Sites Regulate the Stability of ZO-2 Protein and the Sealing of Tight Junctions

Tight junctions (TJs) regulate the transit of ions and molecules through the paracellular pathway in epithelial cells. Zonula occludens 2 (ZO-2) is a cytoplasmic TJ protein. Here, we studied the ubiquitination of hZO-2 employing mutants of SUMOylation site K730 present in the GuK domain and the puta...

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Detalles Bibliográficos
Autores principales: Cano-Cortina, Misael, Alarcón, Lourdes, Miranda, Jael, Huber, Otmar, González-Mariscal, Lorenza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601146/
https://www.ncbi.nlm.nih.gov/pubmed/36291162
http://dx.doi.org/10.3390/cells11203296

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601146/
https://www.ncbi.nlm.nih.gov/pubmed/36291162
http://dx.doi.org/10.3390/cells11203296

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