Cargando…
Salmonella enterica Infections Are Disrupted by Two Small Molecules That Accumulate within Phagosomes and Differentially Damage Bacterial Inner Membranes
Gram-negative bacteria have a robust cell envelope that excludes or expels many antimicrobial agents. However, during infection, host soluble innate immune factors permeabilize the bacterial outer membrane. We identified two small molecules that exploit outer membrane damage to access the bacterial...
Autores principales: | Villanueva, Joseph A., Crooks, Amy L., Nagy, Toni A., Quintana, Joaquin L. J., Dalebroux, Zachary D., Detweiler, Corrella S. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Microbiology
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601186/ https://www.ncbi.nlm.nih.gov/pubmed/36135367 http://dx.doi.org/10.1128/mbio.01790-22 |
Ejemplares similares
-
Autophagy Induction by a Small Molecule Inhibits Salmonella Survival in Macrophages and Mice
por: Nagy, Toni A., et al.
Publicado: (2019) -
A small molecule that disrupts S. Typhimurium membrane voltage without cell lysis reduces bacterial colonization of mice
por: Dombach, Jamie L., et al.
Publicado: (2022) -
Staphylococcal Bacterial Persister Cells, Biofilms, and Intracellular Infection Are Disrupted by JD1, a Membrane-Damaging Small Molecule
por: Dombach, Jamie L., et al.
Publicado: (2021) -
A small molecule that mitigates bacterial infection disrupts Gram-negative cell membranes and is inhibited by cholesterol and neutral lipids
por: Dombach, Jamie L., et al.
Publicado: (2020) -
Salmonella enterica Infection Stimulates Macrophages to Hemophagocytose
por: Pilonieta, M. Carolina, et al.
Publicado: (2014)