Trio-Drug Combination of Sodium Valproate, Baclofen and Thymoquinone Exhibits Synergistic Anticonvulsant Effects in Rats and Neuro-Protective Effects in HEK-293 Cells

Epilepsy is a chronic brain disorder, with anti-epileptic drugs (AEDs) providing relief from hyper-excitability of neurons, but largely failing to restrain neurodegeneration. We investigated a progressive preclinical trial in rats, whereby the test drugs; sodium valproate (SVP; 150 and 300 mg/kg), b...

Descripción completa

Detalles Bibliográficos
Autores principales: Hyder Pottoo, Faheem, Salahuddin, Mohammed, Khan, Firdos Alam, Albaqshi, Batool Taleb, Gomaa, Mohamed S., Abdulla, Fatima S., AlHajri, Noora, Alomary, Mohammad N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601194/
https://www.ncbi.nlm.nih.gov/pubmed/36286014
http://dx.doi.org/10.3390/cimb44100299

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601194/
https://www.ncbi.nlm.nih.gov/pubmed/36286014
http://dx.doi.org/10.3390/cimb44100299

Ejemplares similares