Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3

The camelid single domain antibody, referred to VHH or Nanobody, is considered a versatile tool for various biotechnological and clinical applications because of its favorable biophysical properties. To take advantage of these characteristics and for its application in biotechnology and therapy, res...

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Detalles Bibliográficos
Autores principales: Kinoshita, Seisho, Nakakido, Makoto, Mori, Chinatsu, Kuroda, Daisuke, Caaveiro, Jose M.M., Tsumoto, Kouhei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Full‐length Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601775/
https://www.ncbi.nlm.nih.gov/pubmed/36153698
http://dx.doi.org/10.1002/pro.4450

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601775/
https://www.ncbi.nlm.nih.gov/pubmed/36153698
http://dx.doi.org/10.1002/pro.4450

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