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Intrinsic protein disorder uncouples affinity from binding specificity

Intrinsically disordered proteins (IDPs) and intrinsically disordered regions (IDRs) of proteins often function by molecular recognition, in which they undergo induced folding. Based on prior generalizations, the idea prevails in the IDP field that due to the entropic penalty of induced folding, the...

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Detalles Bibliográficos
Autores principales: Lázár, Tamas, Tantos, Agnes, Tompa, Peter, Schad, Eva
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Inc. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9601785/
https://www.ncbi.nlm.nih.gov/pubmed/36305763
http://dx.doi.org/10.1002/pro.4455