PCSK9 Affects Astrocyte Cholesterol Metabolism and Reduces Neuron Cholesterol Supplying In Vitro: Potential Implications in Alzheimer’s Disease

The Proprotein Convertase Subtilisin/Kexin Type 9 (PCSK9) involvement in Alzheimer’s disease (AD) is poorly investigated. We evaluated the in vitro PCSK9 modulation of astrocyte cholesterol metabolism and neuronal cholesterol supplying, which is fundamental for neuronal functions. Moreover, we inves...

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Detalles Bibliográficos
Autores principales: Papotti, Bianca, Adorni, Maria Pia, Marchi, Cinzia, Zimetti, Francesca, Ronda, Nicoletta, Panighel, Giovanni, Lupo, Maria Giovanna, Vilella, Antonietta, Giuliani, Daniela, Ferri, Nicola, Bernini, Franco
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602670/
https://www.ncbi.nlm.nih.gov/pubmed/36293049
http://dx.doi.org/10.3390/ijms232012192

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602670/
https://www.ncbi.nlm.nih.gov/pubmed/36293049
http://dx.doi.org/10.3390/ijms232012192

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