Sensory Neuron-Specific Deletion of Tropomyosin Receptor Kinase A (TrkA) in Mice Abolishes Osteoarthritis (OA) Pain via NGF/TrkA Intervention of Peripheral Sensitization

Tropomyosin receptor kinase A (TrkA/NTRK1) is a high-affinity receptor for nerve growth factor (NGF), a potent pain mediator. NGF/TrkA signaling elevates synovial sensory neuronal distributions in the joints and causes osteoarthritis (OA) pain. We investigated the mechanisms of pain transmission as...

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Detalles Bibliográficos
Autores principales: O-Sullivan, InSug, Kc, Ranjan, Singh, Gurjit, Das, Vaskar, Ma, Kaige, Li, Xin, Mwale, Fackson, Votta-Velis, Gina, Bruce, Benjamin, Natarajan Anbazhagan, Arivarasu, van Wijnen, Andre J., Im, Hee-Jeong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602682/
https://www.ncbi.nlm.nih.gov/pubmed/36292950
http://dx.doi.org/10.3390/ijms232012076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602682/
https://www.ncbi.nlm.nih.gov/pubmed/36292950
http://dx.doi.org/10.3390/ijms232012076

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