Lipofuscin-Mediated Photic Stress Induces a Dark Toxic Effect on ARPE-19 Cells

Lipofuscin granules from retinal pigment epithelium (RPE) cells contain bisretinoid fluorophores, which are photosensitizers and are phototoxic to cells. In the presence of oxygen, bisretinoids are oxidized to form various products, containing aldehydes and ketones, which are also potentially cytoto...

Descripción completa

Detalles Bibliográficos
Autores principales: Feldman, Tatiana, Ostrovskiy, Dmitriy, Yakovleva, Marina, Dontsov, Alexander, Borzenok, Sergey, Ostrovsky, Mikhail
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602730/
https://www.ncbi.nlm.nih.gov/pubmed/36293088
http://dx.doi.org/10.3390/ijms232012234

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602730/
https://www.ncbi.nlm.nih.gov/pubmed/36293088
http://dx.doi.org/10.3390/ijms232012234

Ejemplares similares