Naturally Acquired Kelch13 Mutations in Plasmodium falciparum Strains Modulate In Vitro Ring-Stage Artemisinin-Based Drug Tolerance and Parasite Survival in Response to Hyperoxia

The ring-stage survival assay was utilized to assess the impact of physiological hyperoxic stress on dihydroartemisinin (DHA) tolerance for a panel of Plasmodium falciparum strains with and without Kelch13 mutations. Strains without naturally acquired Kelch13 mutations or the postulated genetic back...

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Detalles Bibliográficos
Autores principales: Duffy, Sandra, Avery, Vicky M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602862/
https://www.ncbi.nlm.nih.gov/pubmed/36094220
http://dx.doi.org/10.1128/spectrum.01282-21

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602862/
https://www.ncbi.nlm.nih.gov/pubmed/36094220
http://dx.doi.org/10.1128/spectrum.01282-21

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