Esmethadone (REL-1017) and Other Uncompetitive NMDAR Channel Blockers May Improve Mood Disorders via Modulation of Synaptic Kinase-Mediated Signaling

This article presents a mechanism of action hypothesis to explain the rapid antidepressant effects of esmethadone (REL-1017) and other uncompetitive N-methyl-D-aspartate receptor (NMDAR) antagonists and presents a corresponding mechanism of disease hypothesis for major depressive disorder (MDD). Esm...

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Detalles Bibliográficos
Autores principales: Stahl, Stephen M., De Martin, Sara, Mattarei, Andrea, Bettini, Ezio, Pani, Luca, Guidetti, Clotilde, Folli, Franco, de Somer, Marc, Traversa, Sergio, Inturrisi, Charles E., Pappagallo, Marco, Gentilucci, Marco, Alimonti, Andrea, Fava, Maurizio, Manfredi, Paolo L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602945/
https://www.ncbi.nlm.nih.gov/pubmed/36293063
http://dx.doi.org/10.3390/ijms232012196

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602945/
https://www.ncbi.nlm.nih.gov/pubmed/36293063
http://dx.doi.org/10.3390/ijms232012196

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