Virtual Drug Repositioning as a Tool to Identify Natural Small Molecules That Synergize with Lumacaftor in F508del-CFTR Binding and Rescuing

Cystic fibrosis is a hereditary disease mainly caused by the deletion of the Phe 508 (F508del) of the cystic fibrosis transmembrane conductance regulator (CFTR) protein that is thus withheld in the endoplasmic reticulum and rapidly degraded by the ubiquitin/proteasome system. Cystic fibrosis remains...

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Detalles Bibliográficos
Autores principales: Fossa, Paola, Uggeri, Matteo, Orro, Alessandro, Urbinati, Chiara, Rondina, Alessandro, Milanesi, Maria, Pedemonte, Nicoletta, Pesce, Emanuela, Padoan, Rita, Ford, Robert C., Meng, Xin, Rusnati, Marco, D’Ursi, Pasqualina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602983/
https://www.ncbi.nlm.nih.gov/pubmed/36293130
http://dx.doi.org/10.3390/ijms232012274

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9602983/
https://www.ncbi.nlm.nih.gov/pubmed/36293130
http://dx.doi.org/10.3390/ijms232012274

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