Characterization of the RAS/RAF/ERK Signal Cascade as a Novel Regulating Factor in Alpha-Amanitin-Induced Cytotoxicity in Huh-7 Cells

The well-known hepatotoxicity mechanism resulting from alpha-amanitin (α-AMA) exposure arises from RNA polymerase II (RNAP II) inhibition. RNAP Ⅱ inhibition occurs through the dysregulation of mRNA synthesis. However, the signaling pathways in hepatocytes that arise from α-AMA have not yet been full...

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Detalles Bibliográficos
Autores principales: Kim, Doeun, Lee, Min Seo, Sung, Eunji, Lee, Sangkyu, Lee, Hye Suk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603094/
https://www.ncbi.nlm.nih.gov/pubmed/36293151
http://dx.doi.org/10.3390/ijms232012294

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603094/
https://www.ncbi.nlm.nih.gov/pubmed/36293151
http://dx.doi.org/10.3390/ijms232012294

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