Folding Mechanism and Aggregation Propensity of the KH0 Domain of FMRP and Its R138Q Pathological Variant

The K-homology (KH) domains are small, structurally conserved domains found in proteins of different origins characterized by a central conserved βααβ “core” and a GxxG motif in the loop between the two helices of the KH core. In the eukaryotic KHI type, additional αβ elements decorate the “core” at...

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Detalles Bibliográficos
Autores principales: Santorelli, Daniele, Troilo, Francesca, Fata, Francesca, Angelucci, Francesco, Demitri, Nicola, Giardina, Giorgio, Federici, Luca, Catalano, Flavia, Di Matteo, Adele, Travaglini-Allocatelli, Carlo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603430/
https://www.ncbi.nlm.nih.gov/pubmed/36293035
http://dx.doi.org/10.3390/ijms232012178

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603430/
https://www.ncbi.nlm.nih.gov/pubmed/36293035
http://dx.doi.org/10.3390/ijms232012178

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