Cargando…
The Effect of Circumscribed Exposure to the Pan-Aurora Kinase Inhibitor VX-680 on Proliferating Euploid Cells
Small molecule inhibitors of aurora kinases are currently being investigated in oncology clinical trials. The long-term effects of these inhibitors on proliferating euploid cells have not been adequately studied. We examined the effect of the reversible pan-aurora kinase inhibitor VX-680 on p53-comp...
Autores principales: | Liu, Xumei, Shi, Qiong, Choudhry, Namrta, Zhang, Ting, Liu, Hong, Zhang, Shenqiu, Zhang, Jing, Yang, Dun |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603438/ https://www.ncbi.nlm.nih.gov/pubmed/36292957 http://dx.doi.org/10.3390/ijms232012104 |
Ejemplares similares
-
Crystal Structure of Human
Aurora B in Complex with
INCENP and VX-680
por: Elkins, Jonathan M., et al.
Publicado: (2012) -
Evaluation of an Actinomycin D/VX-680 aurora kinase inhibitor combination in p53-based cyclotherapy
por: Rao, Bhavya, et al.
Publicado: (2010) -
RIPK1-dependent cell death: a novel target of the Aurora kinase inhibitor Tozasertib (VX-680)
por: Martens, Sofie, et al.
Publicado: (2018) -
The Aurora kinase B relocation blocker LXY18 triggers mitotic catastrophe selectively in malignant cells
por: Kalashova, Julia, et al.
Publicado: (2023) -
SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers
por: Tagal, Vural, et al.
Publicado: (2017)