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Cytoskeleton Elements Contribute to Prion Peptide-Induced Endothelial Barrier Breakdown in a Blood–Brain Barrier In Vitro System

The mechanisms involved in the interaction of PrP 106-126, a peptide corresponding to the prion protein amyloidogenic region, with the blood–brain barrier (BBB) were studied. PrP 106-126 treatment that was previously shown to impair BBB function, reduced cAMP levels in cultured brain endothelial cel...

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Detalles Bibliográficos
Autores principales: Cooper, Itzik, Cohen-Kashi Malina, Katayun, Levin, Yishai, Gabashvili, Alexandra, Mohar, Boaz, Cagnotto, Alfredo, Salmona, Mario, Teichberg, Vivian I.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603506/
https://www.ncbi.nlm.nih.gov/pubmed/36293002
http://dx.doi.org/10.3390/ijms232012126