Single Point Mutation and Its Role in Specific Pathogenicity to Reveal the Mechanism of Related Protein Families

Pyolysin (PLO) is secreted by Trueperella pyogenes as a water-soluble monomer after forming transmembrane β-barrel channels in the cell membrane by binding cholesterol. Two significantly conserved residues at domain 1 of PLO are mutated, which provides novel evidence of a relationship between confor...

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Detalles Bibliográficos
Autores principales: Liu, Ning, Wang, Xue, Shan, Qiang, Li, Shuxian, Li, Yanan, Chu, Bingxin, Wang, Jiufeng, Zhu, Yaohong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603606/
https://www.ncbi.nlm.nih.gov/pubmed/36214694
http://dx.doi.org/10.1128/spectrum.00923-22

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603606/
https://www.ncbi.nlm.nih.gov/pubmed/36214694
http://dx.doi.org/10.1128/spectrum.00923-22

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