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Single Point Mutation and Its Role in Specific Pathogenicity to Reveal the Mechanism of Related Protein Families
Pyolysin (PLO) is secreted by Trueperella pyogenes as a water-soluble monomer after forming transmembrane β-barrel channels in the cell membrane by binding cholesterol. Two significantly conserved residues at domain 1 of PLO are mutated, which provides novel evidence of a relationship between confor...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Society for Microbiology
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603606/ https://www.ncbi.nlm.nih.gov/pubmed/36214694 http://dx.doi.org/10.1128/spectrum.00923-22 |