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Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus

Aspergillus fumigatus is a deadly opportunistic fungal pathogen responsible for ~100,000 annual deaths. Azoles are the first line antifungal agent used against A. fumigatus, but azole resistance has rapidly evolved making treatment challenging. Caspofungin is an important second-line therapy against...

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Detalles Bibliográficos
Autores principales: Zhao, Shu, Martin-Vicente, Adela, Colabardini, Ana Cristina, Pereira Silva, Lilian, Rinker, David C., Fortwendel, Jarrod R., Goldman, Gustavo Henrique, Gibbons, John G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603777/
https://www.ncbi.nlm.nih.gov/pubmed/36094204
http://dx.doi.org/10.1128/spectrum.00519-22