Cargando…

Genomic and Molecular Identification of Genes Contributing to the Caspofungin Paradoxical Effect in Aspergillus fumigatus

Aspergillus fumigatus is a deadly opportunistic fungal pathogen responsible for ~100,000 annual deaths. Azoles are the first line antifungal agent used against A. fumigatus, but azole resistance has rapidly evolved making treatment challenging. Caspofungin is an important second-line therapy against...

Descripción completa

Detalles Bibliográficos
Autores principales:	Zhao, Shu, Martin-Vicente, Adela, Colabardini, Ana Cristina, Pereira Silva, Lilian, Rinker, David C., Fortwendel, Jarrod R., Goldman, Gustavo Henrique, Gibbons, John G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Microbiology 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603777/ https://www.ncbi.nlm.nih.gov/pubmed/36094204 http://dx.doi.org/10.1128/spectrum.00519-22

Ejemplares similares

Aspergillus fumigatus Transcription Factors Involved in the Caspofungin Paradoxical Effect
por: Valero, Clara, et al.
Publicado: (2020)

The Caspofungin Paradoxical Effect is a Tolerant “Eagle Effect” in the Filamentous Fungal Pathogen Aspergillus fumigatus
por: Valero, Clara, et al.
Publicado: (2022)

Signaling Pathways Governing the Caspofungin Paradoxical Effect in Aspergillus fumigatus
por: Papon, Nicolas, et al.
Publicado: (2020)

Phosphoproteomics of Aspergillus fumigatus Exposed to the Antifungal Drug Caspofungin
por: Mattos, Eliciane Cevolani, et al.
Publicado: (2020)

Aspergillus Fumigatus ZnfA, a Novel Zinc Finger Transcription Factor Involved in Calcium Metabolism and Caspofungin Tolerance
por: Valero, Clara, et al.
Publicado: (2021)

The Aspergillus fumigatus CrzA Transcription Factor Activates Chitin Synthase Gene Expression during the Caspofungin Paradoxical Effect
por: Ries, Laure Nicolas Annick, et al.
Publicado: (2017)

Genome-Wide Association for Itraconazole Sensitivity in Non-resistant Clinical Isolates of Aspergillus fumigatus
por: Zhao, Shu, et al.
Publicado: (2021)

Comparative Genomics Reveals a Single Nucleotide Deletion in pksP That Results in White-Spore Phenotype in Natural Variants of Aspergillus fumigatus
por: Gibbons, John G., et al.
Publicado: (2022)

Aspergillus fumigatus calcium-responsive transcription factors regulate cell wall architecture promoting stress tolerance, virulence and caspofungin resistance
por: de Castro, Patrícia Alves, et al.
Publicado: (2019)

Overexpression of the Aspergillus fumigatus Small GTPase, RsrA, Promotes Polarity Establishment during Germination
por: Martin-Vicente, Adela, et al.
Publicado: (2020)

Differential Support of Aspergillus fumigatus Morphogenesis by Yeast and Human Actins
por: LeClaire, Lawrence L., et al.
Publicado: (2015)

Exploration of Aspergillus fumigatus Ras pathways for novel antifungal drug targets
por: Abdallah, Qusai Al, et al.
Publicado: (2015)

C-terminus Proteolysis and Palmitoylation Cooperate for Optimal Plasma Membrane Localization of RasA in Aspergillus fumigatus
por: Al Abdallah, Qusai, et al.
Publicado: (2018)

SH3‐class Ras guanine nucleotide exchange factors are essential for Aspergillus fumigatus invasive growth
por: Martin‐Vicente, Adela, et al.
Publicado: (2019)

Calcium-Mediated Induction of Paradoxical Growth following Caspofungin Treatment Is Associated with Calcineurin Activation and Phosphorylation in Aspergillus fumigatus
por: Juvvadi, Praveen R., et al.
Publicado: (2015)

Whole-genome sequencing reveals highly specific gene targeting by in vitro assembled Cas9-ribonucleoprotein complexes in Aspergillus fumigatus
por: Al Abdallah, Qusai, et al.
Publicado: (2018)

Loss of Septation Initiation Network (SIN) kinases blocks tissue invasion and unlocks echinocandin cidal activity against Aspergillus fumigatus
por: Souza, Ana Camila Oliveira, et al.
Publicado: (2021)

The Aspergillus fumigatus Phosphoproteome Reveals Roles of High-Osmolarity Glycerol Mitogen-Activated Protein Kinases in Promoting Cell Wall Damage and Caspofungin Tolerance
por: Mattos, Eliciane Cevolani, et al.
Publicado: (2020)

Novel Biological Functions of the NsdC Transcription Factor in Aspergillus fumigatus
por: Alves de Castro, Patrícia, et al.
Publicado: (2021)

The Aspergillus fumigatus farnesyltransferase β-subunit, RamA, mediates growth, virulence, and antifungal susceptibility
por: Norton, Tiffany S., et al.
Publicado: (2017)

Secondary Metabolites Produced during Aspergillus fumigatus and Pseudomonas aeruginosa Biofilm Formation
por: Bastos, Rafael Wesley, et al.
Publicado: (2022)

A Simple and Universal System for Gene Manipulation in Aspergillus fumigatus: In Vitro-Assembled Cas9-Guide RNA Ribonucleoproteins Coupled with Microhomology Repair Templates
por: Al Abdallah, Qusai, et al.
Publicado: (2017)

Mutations in hmg1, Challenging the Paradigm of Clinical Triazole Resistance in Aspergillus fumigatus
por: Rybak, Jeffrey M., et al.
Publicado: (2019)

A Fungus-Specific Protein Domain Is Essential for RasA-Mediated Morphogenetic Signaling in Aspergillus fumigatus
por: Al Abdallah, Qusai, et al.
Publicado: (2016)

Network Modeling Reveals Cross Talk of MAP Kinases during Adaptation to Caspofungin Stress in Aspergillus fumigatus
por: Altwasser, Robert, et al.
Publicado: (2015)

Module-detection approaches for the integration of multilevel omics data highlight the comprehensive response of Aspergillus fumigatus to caspofungin
por: Conrad, T., et al.
Publicado: (2018)

Screening of Chemical Libraries for New Antifungal Drugs against Aspergillus fumigatus Reveals Sphingolipids Are Involved in the Mechanism of Action of Miltefosine
por: dos Reis, Thaila Fernanda, et al.
Publicado: (2021)

Genetic Interactions Between Aspergillus fumigatus Basic Leucine Zipper (bZIP) Transcription Factors AtfA, AtfB, AtfC, and AtfD
por: Silva, Lilian Pereira, et al.
Publicado: (2021)

Putative Membrane Receptors Contribute to Activation and Efficient Signaling of Mitogen-Activated Protein Kinase Cascades during Adaptation of Aspergillus fumigatus to Different Stressors and Carbon Sources
por: Silva, Lilian Pereira, et al.
Publicado: (2020)

Characterization of the Efflux Capability and Substrate Specificity of Aspergillus fumigatus PDR5-like ABC Transporters Expressed in Saccharomyces cerevisiae
por: Esquivel, Brooke D., et al.
Publicado: (2020)

Functional Characterization of Aspergillus nidulans ypkA, a Homologue of the Mammalian Kinase SGK
por: Colabardini, Ana Cristina, et al.
Publicado: (2013)

Chromatin profiling reveals heterogeneity in clinical isolates of the human pathogen Aspergillus fumigatus
por: Colabardini, Ana Cristina, et al.
Publicado: (2022)

Identification of Glucose Transporters in Aspergillus nidulans
por: dos Reis, Thaila Fernanda, et al.
Publicado: (2013)

Caspofungin Treatment of Aspergillus fumigatus Results in ChsG-Dependent Upregulation of Chitin Synthesis and the Formation of Chitin-Rich Microcolonies
por: Walker, Louise A., et al.
Publicado: (2015)

hapE and hmg1 Mutations Are Drivers of cyp51A-Independent Pan-Triazole Resistance in an Aspergillus fumigatus Clinical Isolate
por: Souza, Ana C. O., et al.
Publicado: (2023)

Genomic and Phenotypic Heterogeneity of Clinical Isolates of the Human Pathogens Aspergillus fumigatus, Aspergillus lentulus, and Aspergillus fumigatiaffinis
por: dos Santos, Renato A. C., et al.
Publicado: (2020)

The Influence of Genetic Stability on Aspergillus fumigatus Virulence and Azole Resistance
por: dos Reis, Thaila Fernanda, et al.
Publicado: (2017)

Unraveling Caspofungin Resistance in Cryptococcus neoformans
por: Papon, Nicolas, et al.
Publicado: (2021)

Gliotoxin, a Known Virulence Factor in the Major Human Pathogen Aspergillus fumigatus, Is Also Biosynthesized by Its Nonpathogenic Relative Aspergillus fischeri
por: Knowles, Sonja L., et al.
Publicado: (2020)

Role of Hydrophobins in Aspergillus fumigatus
por: Valsecchi, Isabel, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_nfq5uoakc55u1214qdoi8jfppd