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Determinants and Mechanisms of the Low Fusogenicity and Endosomal Entry of Omicron Subvariants

The rapid spread and strong immune evasion of the SARS-CoV-2 Omicron subvariants has raised serious concerns for the global COVID-19 pandemic. These new variants exhibit reduced fusogenicity and increased endosomal entry pathway utilization compared to the ancestral D614G variant, the underlying mec...

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Detalles Bibliográficos
Autores principales: Qu, Panke, Evans, John P., Kurhade, Chaitanya, Zeng, Cong, Zheng, Yi-Min, Xu, Kai, Shi, Pei-Yong, Xie, Xuping, Liu, Shan-Lu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603825/
https://www.ncbi.nlm.nih.gov/pubmed/36299433
http://dx.doi.org/10.1101/2022.10.15.512322