Novel Class of Proteasome Inhibitors: In Silico and In Vitro Evaluation of Diverse Chloro(trifluoromethyl)aziridines

The ubiquitin-proteasome pathway (UPP) is the major proteolytic system in the cytosol and nucleus of all eukaryotic cells. The role of proteasome inhibitors (PIs) as critical agents for regulating cancer cell death has been established. Aziridine derivatives are well-known alkylating agents employed...

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Detalles Bibliográficos
Autores principales: Ielo, Laura, Patamia, Vincenzo, Citarella, Andrea, Efferth, Thomas, Shahhamzehei, Nasim, Schirmeister, Tanja, Stagno, Claudio, Langer, Thierry, Rescifina, Antonio, Micale, Nicola, Pace, Vittorio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Communication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603864/
https://www.ncbi.nlm.nih.gov/pubmed/36293216
http://dx.doi.org/10.3390/ijms232012363

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603864/
https://www.ncbi.nlm.nih.gov/pubmed/36293216
http://dx.doi.org/10.3390/ijms232012363

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