Drug Repurposing for Cystic Fibrosis: Identification of Drugs That Induce CFTR-Independent Fluid Secretion in Nasal Organoids

Individuals with cystic fibrosis (CF) suffer from severe respiratory disease due to a genetic defect in the cystic fibrosis transmembrane conductance regulator (CFTR) gene, which impairs airway epithelial ion and fluid secretion. New CFTR modulators that restore mutant CFTR function have been recent...

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Detalles Bibliográficos
Autores principales: Rodenburg, Lisa W., Delpiano, Livia, Railean, Violeta, Centeio, Raquel, Pinto, Madalena C., Smits, Shannon M. A., van der Windt, Isabelle S., van Hugten, Casper F. J., van Beuningen, Sam F. B., Rodenburg, Remco N. P., van der Ent, Cornelis K., Amaral, Margarida D., Kunzelmann, Karl, Gray, Michael A., Beekman, Jeffrey M., Amatngalim, Gimano D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603984/
https://www.ncbi.nlm.nih.gov/pubmed/36293514
http://dx.doi.org/10.3390/ijms232012657

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9603984/
https://www.ncbi.nlm.nih.gov/pubmed/36293514
http://dx.doi.org/10.3390/ijms232012657

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